A low opening weekend for Legion with keep Avatars world domination on course as it sits only $9million behind Titanic as i type this. By tomorrow it will have surpassed it. Book of Eli does another respectable week and i'm glad to see The Lovely Bones making a comeback this week. Go see it.
| TW | LW | Title (click to view) | Studio | Weekend Gross | % Change | Theater Count / Change | Average | Total Gross | Budget* | Week # |
| 1 | 1 | Avatar | Fox | $36,000,000 | -15.9% | 3,141 | -144 | $11,461 | $552,797,000 | - | 6 |
| 2 | N | Legion (2010) | SGem | $18,200,000 | - | 2,476 | - | $7,351 | $18,200,000 | $26 | 1 |
| 3 | 2 | The Book of Eli | WB | $17,000,000 | -48.2% | 3,111 | - | $5,464 | $62,003,000 | $80 | 2 |
| 4 | N | The Tooth Fairy | Fox | $14,500,000 | - | 3,344 | - | $4,336 | $14,500,000 | $48 | 1 |
| 5 | 3 | The Lovely Bones | P/DW | $8,800,000 | -48.3% | 2,571 | +8 | $3,423 | $31,624,000 | $65 | 7 |
| 6 | 5 | Sherlock Holmes | WB | $7,115,000 | -28.1% | 2,670 | -503 | $2,665 | $191,564,000 | $90 | 5 |
| 7 | N | Extraordinary Measures | CBS | $7,000,000 | - | 2,549 | - | $2,746 | $7,000,000 | $31 | 1 |
| 8 | 4 | Alvin and the Chipmunks: The Squeakquel | Fox | $6,500,000 | -44.1% | 2,973 | -323 | $2,186 | $204,237,000 | $75 | 5 |
| 9 | 7 | It's Complicated | Uni. | $6,190,000 | -23.7% | 2,301 | -369 | $2,690 | $98,650,000 | $85 | 5 |
| 10 | 6 | The Spy Next Door | LGF | $4,750,000 | -51.2% | 2,924 | - | $1,624 | $18,710,000 | - | 2 |