Avatar holds the top spot again and it's worldwide takings now stand at $1.3Billion.
| TW | LW | Title (click to view) | Studio | Weekend Gross | % Change | Theater Count / Change | Average | Total Gross | Budget* | Week # |
| 1 | 1 | Avatar | Fox | $48,500,000 | -29.2% | 3,422 | -39 | $14,173 | $429,040,000 | - | 4 |
| 2 | 2 | Sherlock Holmes | WB | $16,610,000 | -54.6% | 3,626 | - | $4,581 | $165,178,000 | $90 | 3 |
| 3 | 3 | Alvin and the Chipmunks: The Squeakquel | Fox | $16,300,000 | -53.7% | 3,641 | -106 | $4,477 | $178,184,000 | $75 | 3 |
| 4 | N | Daybreakers | LGF | $15,000,000 | - | 2,523 | - | $5,945 | $15,000,000 | $20 | 1 |
| 5 | 4 | It's Complicated | Uni. | $11,007,000 | -41.5% | 2,955 | +58 | $3,725 | $76,370,000 | $85 | 3 |
| 6 | N | Leap Year | Uni. | $9,165,000 | - | 2,511 | - | $3,650 | $9,165,000 | $19 | 1 |
| 7 | 5 | The Blind Side | WB | $7,750,000 | -34.9% | 2,880 | -46 | $2,691 | $219,197,000 | $29 | 8 |
| 8 | 6 | Up in the Air | Par. | $7,100,000 | -33.8% | 2,218 | +323 | $3,201 | $54,700,000 | $25 | 6 |
| 9 | N | Youth in Revolt | W/Dim. | $7,000,000 | - | 1,873 | - | $3,737 | $7,000,000 | $18 | 1 |
| 10 | 7 | The Princess and the Frog | BV | $4,700,000 | -52.2% | 2,620 | -708 | $1,794 | $92,600,000 | $105 | 7 |
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